Time-resolved imaging refractometry of microbicidal films using quantitative phase microscopy.

Journal Article (Letter)

Quantitative phase microscopy is applied to image temporal changes in the refractive index (RI) distributions of solutions created by microbicidal films undergoing hydration. We present a novel method of using an engineered polydimethylsiloxane structure as a static phase reference to facilitate calibration of the absolute RI across the entire field. We present a study of dynamic structural changes in microbicidal films during hydration and subsequent dissolution. With assumptions about the smoothness of the phase changes induced by these films, we calculate absolute changes in the percentage of film in regions across the field of view.

Full Text

Duke Authors

Cited Authors

  • Rinehart, MT; Drake, TK; Robles, FE; Rohan, LC; Katz, D; Wax, A

Published Date

  • December 2011

Published In

Volume / Issue

  • 16 / 12

Start / End Page

  • 120510 -

PubMed ID

  • 22191912

Pubmed Central ID

  • PMC3253752

Electronic International Standard Serial Number (EISSN)

  • 1560-2281

International Standard Serial Number (ISSN)

  • 1083-3668

Digital Object Identifier (DOI)

  • 10.1117/1.3665439


  • eng