Monoclonal B cell lymphocytosis: clinical and population perspectives.

Journal Article (Journal Article;Review)

Monoclonal B Cell Lymphocytosis (MBL) refers to clones of CLL-like cells that exhibit CLL characteristics that fall short of the numbers required for CLL diagnosis. Data from large CLL kindreds document increased prevalence of MBL suggesting a genetic contribution to its etiology. The molecular features that favor progression of MBL to CLL are poorly understood but an elevated B-cell count is a risk factor for progression. An important consideration when evaluating volunteers from CLL families who are willing to donate bone marrow is that MBL be ruled out since the MBL donor clone could result in a second CLL in the recipient. Further studies of MBL are needed to identify the molecular features and how they evolve during progression.

Full Text

Duke Authors

Cited Authors

  • Caporaso, NE; Marti, GE; Landgren, O; Azzato, E; Weinberg, JB; Goldin, L; Shanafelt, T

Published Date

  • 2010

Published In

Volume / Issue

  • 78 Suppl 1 /

Start / End Page

  • S115 - S119

PubMed ID

  • 20839332

Pubmed Central ID

  • PMC7282703

Electronic International Standard Serial Number (EISSN)

  • 1552-4957

Digital Object Identifier (DOI)

  • 10.1002/cyto.b.20555


  • eng

Conference Location

  • United States