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Clinical research in pancreatic cancer: the Radiation Therapy Oncology Group trials.

Publication ,  Journal Article
Willett, CG; Safran, H; Abrams, RA; Regine, WF; Rich, TA; Gastrointestinal Committee of the Radiation Therapy Oncology Group,
Published in: Int J Radiat Oncol Biol Phys
2003

To summarize the clinical research activities of the Radiation Therapy Oncology Group program in the treatment of patients with locally advanced, as well as resected, pancreatic cancer. Phase II and III clinical trials are underway, examining novel cytotoxic and targeted agents with irradiation (RT) for patients with locally advanced and resected pancreatic cancer.A Phase II study incorporating concurrent paclitaxel with external beam radiotherapy in the locally advanced setting has been completed and recently analyzed. This experience has served as the foundation of a Phase II study using concurrent paclitaxel and gemcitabine with RT followed by R115777, a farnesyltransferase inhibitor, as maintenance therapy. In the adjuvant treatment of pancreatic cancer, an Intergroup Phase III trial has compared "conventional" postoperative chemoirradiation (5-fluorouracil before, after, and during RT) and gemcitabine before and after RT (with 5-fluorouracil during RT). This study has recently closed, meeting its accrual goal. The successor study will evaluate the use of gemcitabine given concurrently with RT, as well as in a maintenance schedule. This report summarizes current and future Radiation Therapy Oncology Group clinical trials in the treatment of patients with localized pancreatic cancer.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

2003

Volume

56

Issue

4 Suppl

Start / End Page

31 / 37

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Radiotherapy, Conformal
  • Quinolones
  • Paclitaxel
  • Oncology & Carcinogenesis
  • Humans
  • Gemcitabine
  • Gastrointestinal Neoplasms
  • Enzyme Inhibitors
  • Disease Progression
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Willett, C. G., Safran, H., Abrams, R. A., Regine, W. F., Rich, T. A., & Gastrointestinal Committee of the Radiation Therapy Oncology Group, . (2003). Clinical research in pancreatic cancer: the Radiation Therapy Oncology Group trials. Int J Radiat Oncol Biol Phys, 56(4 Suppl), 31–37. https://doi.org/10.1016/s0360-3016(03)00446-2
Willett, Christopher G., Howard Safran, Ross A. Abrams, William F. Regine, Tyvin A. Rich, and Tyvin A. Gastrointestinal Committee of the Radiation Therapy Oncology Group. “Clinical research in pancreatic cancer: the Radiation Therapy Oncology Group trials.Int J Radiat Oncol Biol Phys 56, no. 4 Suppl (2003): 31–37. https://doi.org/10.1016/s0360-3016(03)00446-2.
Willett CG, Safran H, Abrams RA, Regine WF, Rich TA, Gastrointestinal Committee of the Radiation Therapy Oncology Group. Clinical research in pancreatic cancer: the Radiation Therapy Oncology Group trials. Int J Radiat Oncol Biol Phys. 2003;56(4 Suppl):31–7.
Willett, Christopher G., et al. “Clinical research in pancreatic cancer: the Radiation Therapy Oncology Group trials.Int J Radiat Oncol Biol Phys, vol. 56, no. 4 Suppl, 2003, pp. 31–37. Pubmed, doi:10.1016/s0360-3016(03)00446-2.
Willett CG, Safran H, Abrams RA, Regine WF, Rich TA, Gastrointestinal Committee of the Radiation Therapy Oncology Group. Clinical research in pancreatic cancer: the Radiation Therapy Oncology Group trials. Int J Radiat Oncol Biol Phys. 2003;56(4 Suppl):31–37.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

2003

Volume

56

Issue

4 Suppl

Start / End Page

31 / 37

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Radiotherapy, Conformal
  • Quinolones
  • Paclitaxel
  • Oncology & Carcinogenesis
  • Humans
  • Gemcitabine
  • Gastrointestinal Neoplasms
  • Enzyme Inhibitors
  • Disease Progression