Intraoperative radiation therapy.

Journal Article (Journal Article;Review)

The modern use of intraoperative radiation therapy (IORT) was initiated by the studies of Abe and colleagues at the University of Kyoto. This work stimulated significant laboratory and clinical investigation into the use of IORT throughout Japan, Europe, and the United States. Because of this experience, single high doses of irradiation can be safely delivered to a tumor volume in appropriate clinical situations. Most importantly, this high dose of additional radiation treatment yields improved local control of selected tumors. Treatment programs of external beam radiation therapy, surgical resection, and IORT for patients with locally advanced primary and recurrent rectal carcinoma and retroperitoneal sarcoma have yielded excellent local control and higher survival rates. The future of IORT will be in the successful integration of this therapy into multimodality treatment programs of chemotherapy, external beam irradiation, and surgery for locally advanced malignancies.

Full Text

Duke Authors

Cited Authors

  • Willett, CG

Published Date

  • October 1, 2001

Published In

Volume / Issue

  • 6 / 5

Start / End Page

  • 209 - 214

PubMed ID

  • 11723741

International Standard Serial Number (ISSN)

  • 1341-9625

Digital Object Identifier (DOI)

  • 10.1007/pl00012107


  • eng

Conference Location

  • Japan