Intraoperative radiation therapy for locally advanced recurrent rectal or rectosigmoid cancer.

Journal Article (Clinical Trial;Journal Article)

Recurrent rectal or rectosigmoid cancer is a difficult therapeutic problem. A treatment program of external beam irradiation, surgery, and intraoperative irradiation has been used for 41 patients. The 5-year actuarial local control and disease-free survival of all 41 patients was 30% and 16%, respectively. Subset analysis demonstrated differences in outcome by extent of surgical resection. The 5-year actuarial local control and disease-free survival of 27 patients undergoing complete resection was 47% and 21%, respectively. By contrast, the outcome of 14 patients undergoing partial resection was poor, with a 5-year actuarial local control and survival of 21% and 7%, respectively. Late complications included soft tissue or peripheral nerve injury, with many of these resolving within 4-18 months. Local control and disease-free survival rates are favorable in comparison with the results achieved by aggressive surgery. Patients who achieve a gross total resection at intraoperative irradiation have a markedly better prognosis than that of patients with residual gross disease.

Full Text

Duke Authors

Cited Authors

  • Wallace, HJ; Willett, CG; Shellito, PC; Coen, JJ; Hoover, HC

Published Date

  • October 1995

Published In

Volume / Issue

  • 60 / 2

Start / End Page

  • 122 - 127

PubMed ID

  • 7564378

International Standard Serial Number (ISSN)

  • 0022-4790

Digital Object Identifier (DOI)

  • 10.1002/jso.2930600211


  • eng

Conference Location

  • United States