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Residual disease after radical surgery or radiation therapy for prostate cancer. Clinical significance and therapeutic implications.

Publication ,  Journal Article
Zietman, AL; Shipley, WU; Willett, CG
Published in: Cancer
February 1, 1993

Radical treatment for prostate cancer aims at complete eradication of tumor. This review of published data makes clear that the goal is less frequently achieved than commonly presumed. Following radical prostatectomy extracapsular disease, carrying a significant risk of local recurrence, is found from 12-68% of the time depending on the clinical tumor stage. Local regrowth is associated with a poorer prognosis. A substantial proportion of patients whose prostate glands are rebiopsied more than 18 months after radiation therapy also have residual tumor. This again predicts for clinical relapse. The likelihood of a positive rebiopsy is dependent on original tumor size and current prostate specific antigen (PSA) levels. Strategies for managing residual disease are critically discussed.

Duke Scholars

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Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

February 1, 1993

Volume

71

Issue

3 Suppl

Start / End Page

959 / 969

Location

United States

Related Subject Headings

  • Urinary Incontinence
  • Urethral Stricture
  • Salvage Therapy
  • Prostatic Neoplasms
  • Prostatectomy
  • Prostate-Specific Antigen
  • Prostate
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Staging
 

Citation

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Zietman, A. L., Shipley, W. U., & Willett, C. G. (1993). Residual disease after radical surgery or radiation therapy for prostate cancer. Clinical significance and therapeutic implications. Cancer, 71(3 Suppl), 959–969. https://doi.org/10.1002/1097-0142(19930201)71:3+<959::aid-cncr2820711411>3.0.co;2-l
Zietman, A. L., W. U. Shipley, and C. G. Willett. “Residual disease after radical surgery or radiation therapy for prostate cancer. Clinical significance and therapeutic implications.Cancer 71, no. 3 Suppl (February 1, 1993): 959–69. https://doi.org/10.1002/1097-0142(19930201)71:3+<959::aid-cncr2820711411>3.0.co;2-l.
Zietman, A. L., et al. “Residual disease after radical surgery or radiation therapy for prostate cancer. Clinical significance and therapeutic implications.Cancer, vol. 71, no. 3 Suppl, Feb. 1993, pp. 959–69. Pubmed, doi:10.1002/1097-0142(19930201)71:3+<959::aid-cncr2820711411>3.0.co;2-l.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

February 1, 1993

Volume

71

Issue

3 Suppl

Start / End Page

959 / 969

Location

United States

Related Subject Headings

  • Urinary Incontinence
  • Urethral Stricture
  • Salvage Therapy
  • Prostatic Neoplasms
  • Prostatectomy
  • Prostate-Specific Antigen
  • Prostate
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Staging