Residual disease after radical surgery or radiation therapy for prostate cancer. Clinical significance and therapeutic implications.

Journal Article (Journal Article;Review)

Radical treatment for prostate cancer aims at complete eradication of tumor. This review of published data makes clear that the goal is less frequently achieved than commonly presumed. Following radical prostatectomy extracapsular disease, carrying a significant risk of local recurrence, is found from 12-68% of the time depending on the clinical tumor stage. Local regrowth is associated with a poorer prognosis. A substantial proportion of patients whose prostate glands are rebiopsied more than 18 months after radiation therapy also have residual tumor. This again predicts for clinical relapse. The likelihood of a positive rebiopsy is dependent on original tumor size and current prostate specific antigen (PSA) levels. Strategies for managing residual disease are critically discussed.

Full Text

Duke Authors

Cited Authors

  • Zietman, AL; Shipley, WU; Willett, CG

Published Date

  • February 1, 1993

Published In

Volume / Issue

  • 71 / 3 Suppl

Start / End Page

  • 959 - 969

PubMed ID

  • 7679046

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19930201)71:3+<959::aid-cncr2820711411>;2-l


  • eng

Conference Location

  • United States