-tetrahydrocannabinol and ethanol: Differential effects on sympathetic activity in differing environmental setting
Serum dopamine β-hydroxylase activity, a useful biochemical index of peripheral sympathetic nervous activity, was measured in rats treated with Δ9-tetrahydrocannabinol or ethanol or both substances. After 7 days of treatment with either substance, serum dopamine β-hydroxylase activity decreased significantly. Combined treatment with both agents enhanced the effects of each given alone. In rats subjected to immobilization stress, treatment with Δ9-tetrahydrocannabinol appeared to potentiate the stress-induced increase in serum enzyme activity. Treatment with ethanol, with or without Δ9-tetrahydrocannabinol, eflectively blocked this increase in enzyme activity. These results show that both substances have significant eflects on the sympathetic nervous system which are critically influenced by environmental setting.
Ng, LKY; Lamprecht, F; Williams, RB; Kopin, IJ
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