Rat fighting behavior: serum dopamine- -hydroxylase and hypothalamic tyrosine hydroxylase.
Journal Article (Journal Article)
Male Sprague-Dawley rats were subjected to 4 weeks of daily periods of immobilization stress. One of two experimental groups was allowed 1 month of recovery. After 4 weeks of stress, there was a significant increase in shockinduced fighting, in the activity of serum dopamine-beta-hydroxylase, and in the activity of hypothalamic tyrosine hydroxylase. The concentration of hypothalamic norepinephrine was not decreased. After 4 weeks of recovery, only serum dopamine-betahydroxylase activity returned to normal; it therefore appears that longterm stress may increase central catecholamine synthesis. possibly resulting in a persistent increase in aggressive behavior.
Full Text
Duke Authors
Cited Authors
- Lamprecht, F; Eichelman, B; Thoa, NB; Williams, RB; Kopin, IJ
Published Date
- September 29, 1972
Published In
Volume / Issue
- 177 / 4055
Start / End Page
- 1214 - 1215
PubMed ID
- 4403515
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.177.4055.1214
Language
- eng
Conference Location
- United States