Rat fighting behavior: serum dopamine- -hydroxylase and hypothalamic tyrosine hydroxylase.

Journal Article (Journal Article)

Male Sprague-Dawley rats were subjected to 4 weeks of daily periods of immobilization stress. One of two experimental groups was allowed 1 month of recovery. After 4 weeks of stress, there was a significant increase in shockinduced fighting, in the activity of serum dopamine-beta-hydroxylase, and in the activity of hypothalamic tyrosine hydroxylase. The concentration of hypothalamic norepinephrine was not decreased. After 4 weeks of recovery, only serum dopamine-betahydroxylase activity returned to normal; it therefore appears that longterm stress may increase central catecholamine synthesis. possibly resulting in a persistent increase in aggressive behavior.

Full Text

Duke Authors

Cited Authors

  • Lamprecht, F; Eichelman, B; Thoa, NB; Williams, RB; Kopin, IJ

Published Date

  • September 29, 1972

Published In

Volume / Issue

  • 177 / 4055

Start / End Page

  • 1214 - 1215

PubMed ID

  • 4403515

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.177.4055.1214


  • eng

Conference Location

  • United States