Barbiturate enhancement of spike frequency adaptation in Aplysia giant neurons.

Published

Journal Article

Pentobarbital and phenobarbital inhibit repetitive firing of action potentials in neurons of Aplysia by enhancing the normal process of spike frequency adaptation. Voltage clamp studies reveal a slowly developing outward current which is unique to neurons demonstrating spike frequency adaptation. Enhancement of this current by barbiturates was demonstrated and is the probable mechanism by which these drugs enhance adaptation. In experiments in which the pH of the applied drug solutions was altered, barbiturates were more effective in increasing both the slow outward current and adaptation at low pH, suggesting the unionized, acid form, of the drug is responsible for these effects. The concentrations of phenobarbital which were effective closely resembled plasma levels expected to be anticonvulsant.

Full Text

Duke Authors

Cited Authors

  • Zbicz, KL; Wilson, WA

Published Date

  • April 1, 1981

Published In

Volume / Issue

  • 217 / 1

Start / End Page

  • 222 - 227

PubMed ID

  • 7205656

Pubmed Central ID

  • 7205656

Electronic International Standard Serial Number (EISSN)

  • 1521-0103

International Standard Serial Number (ISSN)

  • 0022-3565

Language

  • eng