Skip to main content

The effects of amoxapine and ethanol on psychomotor skills related to driving: A placebo and standard controlled study

Publication ,  Journal Article
Wilson, WH; Petrie, WM; Ban, TA; barry, DE
Published in: Progress in Neuro-Psychopharmacology
1981

Eight normal male volunteers were tested under eight different treatment conditions: amoxapine 50 and 100 mg, amitriptyline 50 mg. and placebo--each condition with and without ethanol--(1.3 g/kg body weight), utilizing a double-blind repeated measures latin square design balanced for carry-over. Motor reflex, pursuit rotor and depth perception tests were conducted when blood levels of the active drugs and alcohol were simutaneously at or near peak. Analyses revealed significant effects of amitriptyline and ethanol on the motor reflex and pursuit rotor but not for depth perception tests, and the effects of ethanol appeared to be potentiated by amitriptyline on the pursuit rotor test; this was not true for amoxapine. Although the effects of 100 mg of amoxapine were consistently greater than for 50 mg or placebo, these differences did not reach a statistical significant level. Since amoxapine did not differ significantly from placebo, these results suggest that the effects of amoxapine on driving skills may not be as pronounced as those produced by amitriptyline.

Duke Scholars

Published In

Progress in Neuro-Psychopharmacology

Publication Date

1981

Volume

5

Issue

3

Start / End Page

263 / 270

Related Subject Headings

  • Psychiatry
  • 17 Psychology and Cognitive Sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wilson, W. H., Petrie, W. M., Ban, T. A., & barry, D. E. (1981). The effects of amoxapine and ethanol on psychomotor skills related to driving: A placebo and standard controlled study. Progress in Neuro-Psychopharmacology, 5(3), 263–270.
Wilson, W. H., W. M. Petrie, T. A. Ban, and D. E. barry. “The effects of amoxapine and ethanol on psychomotor skills related to driving: A placebo and standard controlled study.” Progress in Neuro-Psychopharmacology 5, no. 3 (1981): 263–70.
Wilson WH, Petrie WM, Ban TA, barry DE. The effects of amoxapine and ethanol on psychomotor skills related to driving: A placebo and standard controlled study. Progress in Neuro-Psychopharmacology. 1981;5(3):263–70.
Wilson, W. H., et al. “The effects of amoxapine and ethanol on psychomotor skills related to driving: A placebo and standard controlled study.” Progress in Neuro-Psychopharmacology, vol. 5, no. 3, 1981, pp. 263–70.
Wilson WH, Petrie WM, Ban TA, barry DE. The effects of amoxapine and ethanol on psychomotor skills related to driving: A placebo and standard controlled study. Progress in Neuro-Psychopharmacology. 1981;5(3):263–270.

Published In

Progress in Neuro-Psychopharmacology

Publication Date

1981

Volume

5

Issue

3

Start / End Page

263 / 270

Related Subject Headings

  • Psychiatry
  • 17 Psychology and Cognitive Sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
  • 11 Medical and Health Sciences