Acute effects of viloxazine HCl and flurazepam when given alone and in combination on sleep EEG: A double-blind interaction study with normals

Journal Article

Viloxazine, an aryl-oxypropanolamine type β-adreno-receptor antagonist, has been used in the treatment of depression. In a double-blind drug interaction study with flurazepam, a commonly used benzodiazepine hypnotic, viloxazine administered alone decreased the amount of time spent in REM sleep, increased the amount of time in the "light" stages of sleep, and increased the number of transitions to awake. However, no interactive effects of the combined administration of viloxazine and flurazepam could be detected. © 1980 Springer.

Full Text

Duke Authors

Cited Authors

  • Wilson, WH; Freemon, FR; Ban, TA; Petrie, WM; Clinton, CL

Published Date

  • 1980

Published In

Volume / Issue

  • 15 / 2

Start / End Page

  • 68 - 73

International Standard Serial Number (ISSN)

  • 0093-2213

Digital Object Identifier (DOI)

  • 10.1007/BF03003685