Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice.

Journal Article (Journal Article)

Fifty female CBA mice were injected s.c. either with 0.1 ml saline, or with synthetic thymic dipeptide Lys-Glu or with synthetic pineal tetrapeptide Ala-Glu-Asp-Gly both in a single dose of 0.1 microg/animal monthly for five consecutive days from the age of 6 months until natural death. Lys-Glu did not significantly influence the body weight and food consumption, free radical processes and estrus function in mice and did increase their physical activity with the subsequent decrease in spontaneous lung adenomas incidence. The pineal peptide treatment was failed to modify the food consumption and physical strength of mice, and was followed by the increase in the body weight, mean survival (by 5.3%, P<0.05) and maximum (by 10 months), by slow down of the ageing of estrus function, by the decrease in body temperature, physical activity, free radical processes and spontaneous tumor incidence (mainly, lung adenomas) in mice. These data suggest the geroprotector potential of the pineal peptide.

Full Text

Duke Authors

Cited Authors

  • Anisimov, VN; Khavinson, VK; Mikhalski, AI; Yashin, AI

Published Date

  • January 2001

Published In

Volume / Issue

  • 122 / 1

Start / End Page

  • 41 - 68

PubMed ID

  • 11163623

Electronic International Standard Serial Number (EISSN)

  • 1872-6216

International Standard Serial Number (ISSN)

  • 0047-6374

Digital Object Identifier (DOI)

  • 10.1016/s0047-6374(00)00184-6


  • eng