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Melatonin increases both life span and tumor incidence in female CBA mice.

Publication ,  Journal Article
Anisimov, VN; Zavarzina, NY; Zabezhinski, MA; Popovich, IG; Zimina, OA; Shtylick, AV; Arutjunyan, AV; Oparina, TI; Prokopenko, VM; Mikhalski, AI ...
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences
July 2001

From the age of 6 months until their natural deaths, female CBA mice were given melatonin with their drinking water (20 mg/l) for 5 consecutive days every month. Intact mice served as controls. The results of this study show that the consumption of melatonin did not significantly influence food consumption, but it did increase the body weight of older mice; it did not influence physical strength or the presence of fatigue; it decreased locomotor activity and body temperature; it inhibited free radical processes in serum, brain, and liver; it slowed down the age-related switching-off of estrous function; and it increased life span. However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice. For this reason, we concluded that it would be premature to recommend melatonin as a geroprotector for long-term use.

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Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

July 2001

Volume

56

Issue

7

Start / End Page

B311 / B323

Related Subject Headings

  • Neoplasms
  • Models, Theoretical
  • Mice, Inbred CBA
  • Mice
  • Melatonin
  • Longevity
  • Locomotion
  • Liver
  • Incidence
  • Gerontology
 

Citation

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Anisimov, V. N., Zavarzina, N. Y., Zabezhinski, M. A., Popovich, I. G., Zimina, O. A., Shtylick, A. V., … Yashin, A. I. (2001). Melatonin increases both life span and tumor incidence in female CBA mice. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 56(7), B311–B323. https://doi.org/10.1093/gerona/56.7.b311
Anisimov, V. N., N. Y. Zavarzina, M. A. Zabezhinski, I. G. Popovich, O. A. Zimina, A. V. Shtylick, A. V. Arutjunyan, et al. “Melatonin increases both life span and tumor incidence in female CBA mice.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 56, no. 7 (July 2001): B311–23. https://doi.org/10.1093/gerona/56.7.b311.
Anisimov VN, Zavarzina NY, Zabezhinski MA, Popovich IG, Zimina OA, Shtylick AV, et al. Melatonin increases both life span and tumor incidence in female CBA mice. The journals of gerontology Series A, Biological sciences and medical sciences. 2001 Jul;56(7):B311–23.
Anisimov, V. N., et al. “Melatonin increases both life span and tumor incidence in female CBA mice.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 56, no. 7, July 2001, pp. B311–23. Epmc, doi:10.1093/gerona/56.7.b311.
Anisimov VN, Zavarzina NY, Zabezhinski MA, Popovich IG, Zimina OA, Shtylick AV, Arutjunyan AV, Oparina TI, Prokopenko VM, Mikhalski AI, Yashin AI. Melatonin increases both life span and tumor incidence in female CBA mice. The journals of gerontology Series A, Biological sciences and medical sciences. 2001 Jul;56(7):B311–B323.
Journal cover image

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

July 2001

Volume

56

Issue

7

Start / End Page

B311 / B323

Related Subject Headings

  • Neoplasms
  • Models, Theoretical
  • Mice, Inbred CBA
  • Mice
  • Melatonin
  • Longevity
  • Locomotion
  • Liver
  • Incidence
  • Gerontology