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Heating stress patterns in Caenorhabditis elegans longevity and survivorship.

Publication ,  Journal Article
Michalski, AI; Johnson, TE; Cypser, JR; Yashin, AI
Published in: Biogerontology
January 2001

Survival data from Caenorhabditis elegans strain TJ1060 (spe-9; fer-15) following brief exposure to 35 degrees C have been investigated. Three experiments with 3-day-old worms were conducted with heat duration ranging between 0 and 12 hours. A statistically significant increase in life expectancy was observed in the groups heated for less than 2 hours, as compared to the unheated control groups. In different experiments P-values for the observed life spans under the hypothesis that heating has no influence on longevity were P < 0.004 after 0.5 hour heat, P < 0.012 after 1 hour heat and P < 0.055 after 2 hours of heating. A biphasic survival model with Gamma distributed frailty has been constructed to describe the survival of worms after heating. The increase in the remaining life expectancy is determined by more effective protection by heat-induced substances in the ages yanger than 27 days. The unheated control group demonstrated acquired heterogeneity of frailty with chronological age while the heat-induced substances defend the worms in a universal way and protect against the development of frailty.

Duke Scholars

Published In

Biogerontology

DOI

EISSN

1573-6768

ISSN

1389-5729

Publication Date

January 2001

Volume

2

Issue

1

Start / End Page

35 / 44

Related Subject Headings

  • Time Factors
  • Stress, Physiological
  • Longevity
  • Life Expectancy
  • Heating
  • Heat-Shock Response
  • Gerontology
  • Energy Metabolism
  • Caenorhabditis elegans
  • Animals
 

Citation

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Michalski, A. I., Johnson, T. E., Cypser, J. R., & Yashin, A. I. (2001). Heating stress patterns in Caenorhabditis elegans longevity and survivorship. Biogerontology, 2(1), 35–44. https://doi.org/10.1023/a:1010091315368
Michalski, A. I., T. E. Johnson, J. R. Cypser, and A. I. Yashin. “Heating stress patterns in Caenorhabditis elegans longevity and survivorship.Biogerontology 2, no. 1 (January 2001): 35–44. https://doi.org/10.1023/a:1010091315368.
Michalski AI, Johnson TE, Cypser JR, Yashin AI. Heating stress patterns in Caenorhabditis elegans longevity and survivorship. Biogerontology. 2001 Jan;2(1):35–44.
Michalski, A. I., et al. “Heating stress patterns in Caenorhabditis elegans longevity and survivorship.Biogerontology, vol. 2, no. 1, Jan. 2001, pp. 35–44. Epmc, doi:10.1023/a:1010091315368.
Michalski AI, Johnson TE, Cypser JR, Yashin AI. Heating stress patterns in Caenorhabditis elegans longevity and survivorship. Biogerontology. 2001 Jan;2(1):35–44.
Journal cover image

Published In

Biogerontology

DOI

EISSN

1573-6768

ISSN

1389-5729

Publication Date

January 2001

Volume

2

Issue

1

Start / End Page

35 / 44

Related Subject Headings

  • Time Factors
  • Stress, Physiological
  • Longevity
  • Life Expectancy
  • Heating
  • Heat-Shock Response
  • Gerontology
  • Energy Metabolism
  • Caenorhabditis elegans
  • Animals