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Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen

Publication ,  Journal Article
Zalutsky, MR; Bast, RC; Knapp, RC
Published in: Nuclear Medicine and Biology
January 1, 1989

The pharmacokinetics of 131 I-labeled OC 125 F(ab') 2 antibody fragment were investigated in athymic mice bearing OVCAR-3 ovarian carcinoma xenografts, a model in which the CA 125 antigen is present in serum. Nine antibody doses between 0.1 an 650 μg were studied. Optimal tumor to normal tissue ratios were obtained at 100-200 μg of F(ab') 2 . At most antibody doses, the pre-injection level of circulating CA 125 appeared to influence the localization of 131 I activity in tumor, liver and spleen.

Duke Scholars

Published In

Nuclear Medicine and Biology

ISSN

0883-2897

Publication Date

January 1, 1989

Volume

16

Issue

4

Start / End Page

405 / 411
 

Citation

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ICMJE
MLA
NLM
Zalutsky, M. R., Bast, R. C., & Knapp, R. C. (1989). Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen. Nuclear Medicine and Biology, 16(4), 405–411.
Zalutsky, M. R., R. C. Bast, and R. C. Knapp. “Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen.” Nuclear Medicine and Biology 16, no. 4 (January 1, 1989): 405–11.
Zalutsky MR, Bast RC, Knapp RC. Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen. Nuclear Medicine and Biology. 1989 Jan 1;16(4):405–11.
Zalutsky, M. R., et al. “Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen.” Nuclear Medicine and Biology, vol. 16, no. 4, Jan. 1989, pp. 405–11.
Zalutsky MR, Bast RC, Knapp RC. Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen. Nuclear Medicine and Biology. 1989 Jan 1;16(4):405–411.

Published In

Nuclear Medicine and Biology

ISSN

0883-2897

Publication Date

January 1, 1989

Volume

16

Issue

4

Start / End Page

405 / 411