Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen
The pharmacokinetics of 131 I-labeled OC 125 F(ab') 2 antibody fragment were investigated in athymic mice bearing OVCAR-3 ovarian carcinoma xenografts, a model in which the CA 125 antigen is present in serum. Nine antibody doses between 0.1 an 650 μg were studied. Optimal tumor to normal tissue ratios were obtained at 100-200 μg of F(ab') 2 . At most antibody doses, the pre-injection level of circulating CA 125 appeared to influence the localization of 131 I activity in tumor, liver and spleen.
Zalutsky, MR; Bast, RC; Knapp, RC
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