Use of liposomes as carriers for radiation synovectomy.
Journal Article
Using [99mTc]pertechnetate as an aqueous space marker, the permeability of liposomes composed of seven different mixtures of distearoylphosphatidylcholine (DSPC) and sphingomyelin (SM) was determined. Liposomes containing 20-33% SM were the least permeable in the presence of rheumatoid synovial fluid. Following injection of 99mTc-containing liposomes into the knee joints of rabbits, retention of 99mTc in the knee was more than 200 times greater than following injection of nonencapsulated [99mTc]pertechnetate. The knee clearance biologic half time of 99mTc with DSPC/SM (4:1) liposomes was 64 h. Most of the activity that had leaked from the knee was not found in extra-articular tissues, suggesting rapid excretion. When DSPC/SM (4:1) liposomes were labeled with 111In(oxine), a knee clearance biologic half time of greater than 1200 h was observed.
Full Text
Duke Authors
Cited Authors
- Zalutsky, MR; Noska, MA; Gallagher, PW; Shortkroff, S; Sledge, CB
Published Date
- 1988
Published In
Volume / Issue
- 15 / 2
Start / End Page
- 151 - 156
PubMed ID
- 2835332
Pubmed Central ID
- 2835332
International Standard Serial Number (ISSN)
- 0883-2897
Digital Object Identifier (DOI)
- 10.1016/0883-2897(88)90081-5
Language
- eng
Conference Location
- England