Use of liposomes as carriers for radiation synovectomy

Published

Journal Article

Using [ 99m Tc]pertechnetate as an aqueous space marker, the permeability of liposomes composed of seven different mixtures of distearoylphosphatidylcholine (DSPC) and sphingomyelin (SM) was determined. Liposomes containing 20-33% SM were the least permeable in the presence of rheumatoid synovial fluid. Following injection of 99m Tc-containing liposomes into the knee joints of rabbits, retention of 99 mTc in the knee was more than 200 times greater than following injection of nonencapsulated [ 99m Tc]pertechnetate. The knee clearance biologic half time of 99m Tc with DSPC/SM (4:1) liposomes was 64 h. Most of the activity that had leaked from the knee was not found in extra-articular tissues, suggesting rapid excretion. When DSPC/SM (4:1) liposomes were labeled with 111 In(oxine), a knee clearance biologic half time of greater than 1200 h was observed.

Duke Authors

Cited Authors

  • Zalutsky, MR; Noska, MA; Gallagher, PW; Shortkroff, S; Sledge, CB

Published Date

  • January 1, 1988

Published In

Volume / Issue

  • 15 / 2

Start / End Page

  • 151 - 156

International Standard Serial Number (ISSN)

  • 0883-2897

Citation Source

  • Scopus