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Use of radiolabeled monoclonal anti-B1 antibody for B lymphocyte imaging in rhesus monkeys.

Publication ,  Journal Article
Letvin, NL; Zalutsky, MR; Lambert, JM; Chalifoux, LV; Nadler, LM; Schlossman, SF; Atkins, HL
Published in: Int J Rad Appl Instrum B
1987

Imaging tissues rich in B lymphocytes in man using a radiolabeled monoclonal anti-B cell antibody would be extremely useful in the clinical staging of non-Hodgkins lymphomas. Studies were done in rhesus monkeys using radiolabeled monoclonal anti-B1 antibody to determine the feasibility of such an approach. Immunohistologic studies demonstrated that infused monoclonal anti-B1 binds in vivo with specificity to B cells in lymph nodes and spleen. The kinetics of clearance of 131I-labeled anti-B1 were determined. The B lymphocyte-rich spleen could be readily visualized by gamma camera scanning without significant background and without the need for image intensification or blood background subtraction techniques. These data support the feasibility of using anti-B1 for staging B cell lymphomas in man.

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Published In

Int J Rad Appl Instrum B

DOI

ISSN

0883-2897

Publication Date

1987

Volume

14

Issue

2

Start / End Page

99 / 105

Location

England

Related Subject Headings

  • Radionuclide Imaging
  • Macaca mulatta
  • Lymph Nodes
  • Iodine Radioisotopes
  • Iodides
  • Immunoenzyme Techniques
  • Half-Life
  • B-Lymphocytes
  • Antibodies, Monoclonal
  • Animals
 

Citation

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Letvin, N. L., Zalutsky, M. R., Lambert, J. M., Chalifoux, L. V., Nadler, L. M., Schlossman, S. F., & Atkins, H. L. (1987). Use of radiolabeled monoclonal anti-B1 antibody for B lymphocyte imaging in rhesus monkeys. Int J Rad Appl Instrum B, 14(2), 99–105. https://doi.org/10.1016/0883-2897(87)90138-3
Letvin, N. L., M. R. Zalutsky, J. M. Lambert, L. V. Chalifoux, L. M. Nadler, S. F. Schlossman, and H. L. Atkins. “Use of radiolabeled monoclonal anti-B1 antibody for B lymphocyte imaging in rhesus monkeys.Int J Rad Appl Instrum B 14, no. 2 (1987): 99–105. https://doi.org/10.1016/0883-2897(87)90138-3.
Letvin NL, Zalutsky MR, Lambert JM, Chalifoux LV, Nadler LM, Schlossman SF, et al. Use of radiolabeled monoclonal anti-B1 antibody for B lymphocyte imaging in rhesus monkeys. Int J Rad Appl Instrum B. 1987;14(2):99–105.
Letvin, N. L., et al. “Use of radiolabeled monoclonal anti-B1 antibody for B lymphocyte imaging in rhesus monkeys.Int J Rad Appl Instrum B, vol. 14, no. 2, 1987, pp. 99–105. Pubmed, doi:10.1016/0883-2897(87)90138-3.
Letvin NL, Zalutsky MR, Lambert JM, Chalifoux LV, Nadler LM, Schlossman SF, Atkins HL. Use of radiolabeled monoclonal anti-B1 antibody for B lymphocyte imaging in rhesus monkeys. Int J Rad Appl Instrum B. 1987;14(2):99–105.

Published In

Int J Rad Appl Instrum B

DOI

ISSN

0883-2897

Publication Date

1987

Volume

14

Issue

2

Start / End Page

99 / 105

Location

England

Related Subject Headings

  • Radionuclide Imaging
  • Macaca mulatta
  • Lymph Nodes
  • Iodine Radioisotopes
  • Iodides
  • Immunoenzyme Techniques
  • Half-Life
  • B-Lymphocytes
  • Antibodies, Monoclonal
  • Animals