Use of radiolabeled monoclonal anti-B1 antibody for B lymphocyte imaging in rhesus monkeys

Published

Journal Article

Imaging tissues rich in B lymphocytes in man using a radiolabeled monoclonal anti-B cell antibody would be extremely useful in the clinical staging of non Hodgkins lymphomas. Studies were done in rhesus monkeys using radiolabeled monoclonal anti-B antibody to determine the feasibility of such an approach. Immunohistologic studies demonstrated that infused monoclonal anti-B1 binds in vivo with specificity to B cells in lymph nodes and spleen. The kinetics of clearance of 131I-labeled anti-B1 were determined. The B lymphocyte-rich spleen could be readily visualized by gamma camera scanning without significant background and without the need for image intensification or blood background subtraction techniques. These data support the feasibility of using anti-B1 for staging B cell lymphomas in man.

Full Text

Duke Authors

Cited Authors

  • Letvin, NL; Zalutsky, MR; Lambert, JM; Chalifoux, LV; Nadler, LM; Schlossman, SF; Atkins, HL

Published Date

  • January 1, 1987

Published In

Volume / Issue

  • 14 / 2

Start / End Page

  • 99 - 105

International Standard Serial Number (ISSN)

  • 0969-8051

Digital Object Identifier (DOI)

  • 10.1016/0883-2897(87)90138-3

Citation Source

  • Scopus