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Treatment of rheumatoid synovitis of the knee with intraarticular injection of dysprosium 165-ferric hydroxide macroaggregates.

Publication ,  Journal Article
Sledge, CB; Zuckerman, JD; Zalutsky, MR; Atcher, RW; Shortkroff, S; Lionberger, DR; Rose, HA; Hurson, BJ; Lankenner, PA; Anderson, RJ
Published in: Arthritis Rheum
February 1986

One hundred eight knees of 93 patients with seropositive rheumatoid arthritis and persistent synovitis of the knee were treated with an intraarticular injection of 270 mCi of dysprosium 165 bound to ferric hydroxide macroaggregate. Leakage of radioactivity from the injected joint was minimal. Mean leakage to the venous blood 3 hours after injection was 0.11% of the injected dose; this corresponds to a mean whole body dose of 0.2 rads. Mean leakage to the liver 24 hours after injection was 0.64% of the injected dose; this corresponds to a mean liver dose of 3.2 rads. In 7 additional patients examined, there was negligible or near negligible activity found in the draining inguinal lymph nodes. One-year followup was possible for 74 knees (63 patients). Sixty-one percent of the knees had good results, 23% had fair results, and 16% had poor results. There was a direct correlation between the radiographic stage and response to treatment. In knees with stage I radiographic changes, 72% showed good results; 93% showed improvement. In knees with stage II changes, 59% showed good results; 81% showed improvement. These preliminary results indicate that dysprosium 165-ferric hydroxide macroaggregate is an effective agent for radiation synovectomy. The low leakage rates observed offer a definite advantage over agents previously used.

Duke Scholars

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Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

February 1986

Volume

29

Issue

2

Start / End Page

153 / 159

Location

United States

Related Subject Headings

  • Time Factors
  • Synovitis
  • Sodium Pertechnetate Tc 99m
  • Radiotherapy Dosage
  • Radionuclide Imaging
  • Radioisotopes
  • Pilot Projects
  • Middle Aged
  • Male
  • Lymph Nodes
 

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Sledge, C. B., Zuckerman, J. D., Zalutsky, M. R., Atcher, R. W., Shortkroff, S., Lionberger, D. R., … Anderson, R. J. (1986). Treatment of rheumatoid synovitis of the knee with intraarticular injection of dysprosium 165-ferric hydroxide macroaggregates. Arthritis Rheum, 29(2), 153–159. https://doi.org/10.1002/art.1780290201
Sledge, C. B., J. D. Zuckerman, M. R. Zalutsky, R. W. Atcher, S. Shortkroff, D. R. Lionberger, H. A. Rose, B. J. Hurson, P. A. Lankenner, and R. J. Anderson. “Treatment of rheumatoid synovitis of the knee with intraarticular injection of dysprosium 165-ferric hydroxide macroaggregates.Arthritis Rheum 29, no. 2 (February 1986): 153–59. https://doi.org/10.1002/art.1780290201.
Sledge CB, Zuckerman JD, Zalutsky MR, Atcher RW, Shortkroff S, Lionberger DR, et al. Treatment of rheumatoid synovitis of the knee with intraarticular injection of dysprosium 165-ferric hydroxide macroaggregates. Arthritis Rheum. 1986 Feb;29(2):153–9.
Sledge, C. B., et al. “Treatment of rheumatoid synovitis of the knee with intraarticular injection of dysprosium 165-ferric hydroxide macroaggregates.Arthritis Rheum, vol. 29, no. 2, Feb. 1986, pp. 153–59. Pubmed, doi:10.1002/art.1780290201.
Sledge CB, Zuckerman JD, Zalutsky MR, Atcher RW, Shortkroff S, Lionberger DR, Rose HA, Hurson BJ, Lankenner PA, Anderson RJ. Treatment of rheumatoid synovitis of the knee with intraarticular injection of dysprosium 165-ferric hydroxide macroaggregates. Arthritis Rheum. 1986 Feb;29(2):153–159.
Journal cover image

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

February 1986

Volume

29

Issue

2

Start / End Page

153 / 159

Location

United States

Related Subject Headings

  • Time Factors
  • Synovitis
  • Sodium Pertechnetate Tc 99m
  • Radiotherapy Dosage
  • Radionuclide Imaging
  • Radioisotopes
  • Pilot Projects
  • Middle Aged
  • Male
  • Lymph Nodes