Frontoparietal attentional network activation differs between smokers and nonsmokers during affective cognition.

Journal Article (Journal Article)

Smoking withdrawal-induced disruption of affect and cognition is associated with dysregulated prefrontal brain function, although little is known regarding the neural foci of smoker-nonsmoker differences during affective cognition. Thus, the current study used functional magnetic resonance imaging (fMRI) to identify smoker-nonsmoker differences in affective cognition. Thirty-four healthy volunteers (17 smokers, 17 nonsmokers) underwent fMRI during an affective Stroop task (aST). The aST includes emotional cue-reactivity trials, and response selection trials that contain either neutral or negative emotional distractors. Smokers had less activation during negative cue-reactivity trials in regions subserving emotional awareness (i.e., posterior cingulate), inhibitory control (i.e., inferior frontal gyrus) and conflict resolution (i.e., anterior cingulate); during response-selection trials with negative emotional distractors, smokers had greater activation in a frontoparietal attentional network (i.e., middle frontal and supramarginal gyri). Exploratory analyses revealed that task accuracy was positively correlated with anterior cingulate cortex and inferior frontal gyrus response on fMRI. These findings suggests that chronic nicotine use may reduce inhibitory control and conflict resolution of emotional distraction, and result in recruiting additional attentional resources during emotional interference on cognition.

Full Text

Duke Authors

Cited Authors

  • Froeliger, B; Modlin, LA; Kozink, RV; Wang, L; Garland, EL; Addicott, MA; McClernon, FJ

Published Date

  • January 30, 2013

Published In

Volume / Issue

  • 211 / 1

Start / End Page

  • 57 - 63

PubMed ID

  • 23154092

Pubmed Central ID

  • PMC3557750

Electronic International Standard Serial Number (EISSN)

  • 1872-7123

Digital Object Identifier (DOI)

  • 10.1016/j.pscychresns.2012.05.002


  • eng

Conference Location

  • Ireland