Increased Rates of Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) Graft Failure and Dislocation in Glaucomatous Eyes with Aqueous Shunts.

Journal Article


To investigate the rates of Descemet's stripping automated endothelial keratoplasty (DSAEK) graft dislocation and failure in glaucomatous eyes, including eyes with history of trabeculectomy and/or aqueous shunts.


A retrospective, case-control study on a total of 424 consecutive eyes undergoing DSAEK at an academic setting compared 96 glaucomatous eyes to a control group of 328 eyes. Pre- and post DSAEK procedure data was aggregated for up to 2 years (mean follow-up, 6.5±6.9 months) including rates of graft dislocation and failure.


Out of 96 glaucomatous eyes, 20 had undergone trabeculectomy, 27 had received one or more aqueous shunts, 12 had undergone both procedures and 37 were on medical therapy. Complete DSAEK graft dislocation and failure occurred in 2.7% and 3% of non-glaucomatous patients, respectively. Eyes with history of aqueous shunt surgery experienced graft dislocation and failure rates of 26.0% (OR=4.6, 95% CI 1.5-13.7, p=0.0067) and 26.0% (OR=10.3, 95% CI 3.8-27.1, p<0.0001), respectively. In contrast, glaucomatous eyes only on medical therapy (p=0.13) or with history of trabeculectomy (p>0.40) had no significant increase in graft dislocation or failure rates.


Eyes with medically controlled glaucoma or prior trabeculectomy demonstrated comparable rates of graft dislocation and failure as compared to controls. Aqueous shunt surgery was associated with increased rates of graft dislocation and failure after DSAEK.

Full Text

Duke Authors

Cited Authors

  • Decroos, FC; Delmonte, DW; Chow, JH; Stinnett, SS; Kim, T; Carlson, AN; Afshari, NA

Published Date

  • July 2012

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 203 - 213

PubMed ID

  • 23264862

Pubmed Central ID

  • 23264862

Electronic International Standard Serial Number (EISSN)

  • 2008-322X

International Standard Serial Number (ISSN)

  • 2008-2010


  • eng