Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation.


Journal Article

The increased demand on protein folding in the endoplasmic reticulum (ER) during bacterial infection activates the unfolded protein response (UPR). OCTR-1--a G protein-coupled catecholamine receptor expressed in neurons--suppresses innate immunity by downregulating a non-canonical UPR pathway and the p38 MAPK pathway. Here, we show that OCTR-1 also regulates the canonical UPR pathway, which is controlled by XBP-1, at the organismal level. Importantly, XBP-1 is not under OCTR-1 control during development, only at the adult stage. Our results indicate that the nervous system temporally controls the UPR pathway to maintain ER homeostasis during development and immune activation.

Full Text

Cited Authors

  • Sun, J; Liu, Y; Aballay, A

Published Date

  • September 2012

Published In

Volume / Issue

  • 13 / 9

Start / End Page

  • 855 - 860

PubMed ID

  • 22791024

Pubmed Central ID

  • 22791024

Electronic International Standard Serial Number (EISSN)

  • 1469-3178

International Standard Serial Number (ISSN)

  • 1469-221X

Digital Object Identifier (DOI)

  • 10.1038/embor.2012.100


  • eng