Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes.


Journal Article

The unfolded protein response (UPR), which is activated when unfolded or misfolded proteins accumulate in the endoplasmic reticulum, has been implicated in the normal physiology of immune defense and in several human diseases, including diabetes, cancer, neurodegenerative disease, and inflammatory disease. In this study, we found that the nervous system controlled the activity of a noncanonical UPR pathway required for innate immunity in Caenorhabditis elegans. OCTR-1, a putative octopamine G protein-coupled catecholamine receptor (GPCR, G protein-coupled receptor), functioned in sensory neurons designated ASH and ASI to actively suppress innate immune responses by down-regulating the expression of noncanonical UPR genes pqn/abu in nonneuronal tissues. Our findings suggest a molecular mechanism by which the nervous system may sense inflammatory responses and respond by controlling stress-response pathways at the organismal level.

Full Text

Cited Authors

  • Sun, J; Singh, V; Kajino-Sakamoto, R; Aballay, A

Published Date

  • May 2011

Published In

Volume / Issue

  • 332 / 6030

Start / End Page

  • 729 - 732

PubMed ID

  • 21474712

Pubmed Central ID

  • 21474712

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1203411


  • eng