A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection.
Yersinia pestis has acquired a variety of complex strategies that enable the bacterium to overcome defenses in different hosts and ensure its survival and successful transmission. A full-genome microarray analysis on Caenorhabditis elegans infected with Y. pestis shows enrichment in genes that are markers of innate immune responses and regulated by a conserved PMK-1/p38 MAPK. Consistent with a role in regulating expression of immune effectors, inhibition of PMK-1/p38 by mutation or RNA interference enhances susceptibility to Y. pestis. Further studies of mosaic animals where PMK-1/p38 is exclusively inhibited or overexpressed in a tissue-specific manner indicate that PMK-1/p38 controls expression of a CUB-like family of immune genes at the cell-autonomous level. Given the conserved nature of PMK-1/p38 MAPK-mediated signaling and innate immune responses, PMK-1/p38 MAPK may play a role in the immune response against Y. pestis in natural hosts.
Duke Scholars
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- p38 Mitogen-Activated Protein Kinases
- Yersinia pestis
- Reverse Transcriptase Polymerase Chain Reaction
- RNA, Messenger
- Plague
- Oligonucleotide Array Sequence Analysis
- Mitogen-Activated Protein Kinases
- Gene Expression Profiling
- Flow Cytometry
- Caenorhabditis elegans Proteins
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- p38 Mitogen-Activated Protein Kinases
- Yersinia pestis
- Reverse Transcriptase Polymerase Chain Reaction
- RNA, Messenger
- Plague
- Oligonucleotide Array Sequence Analysis
- Mitogen-Activated Protein Kinases
- Gene Expression Profiling
- Flow Cytometry
- Caenorhabditis elegans Proteins