Nonalcoholic fatty liver disease as a complication of insulin resistance.


Journal Article (Review)

Nonalcoholic fatty liver disease (NAFLD) refers to a spectrum of liver damage ranging from simple steatosis to nonalcoholic steatohepatitis, advanced fibrosis, and rarely, progression to cirrhosis. The pathogenesis of NAFLD is thought to be related to insulin resistance and oxidant stress. Truncal obesity, dyslipidema, hypertension, and hyperglycemia are strongly associated with NAFLD; therefore, management of NAFLD entails identification and treatment of metabolic risk factors, improving insulin sensitivity, and increasing antioxidant defenses in the liver. This article briefly summarizes advances in our understanding of the relationship between NAFLD and the insulin resistance (metabolic) syndrome, its prevalence, natural history, and treatment.

Full Text

Duke Authors

Cited Authors

  • Abdelmalek, MF; Diehl, AM

Published Date

  • November 2007

Published In

Volume / Issue

  • 91 / 6

Start / End Page

  • 1125 - ix

PubMed ID

  • 17964913

Pubmed Central ID

  • 17964913

International Standard Serial Number (ISSN)

  • 0025-7125

Digital Object Identifier (DOI)

  • 10.1016/j.mcna.2007.06.001


  • eng

Conference Location

  • United States