Sarin causes altered time course of mRNA expression of alpha tubulin in the central nervous system of rats.

Published

Journal Article

Sarin induced neurotoxicity is suspected to be one of the key factors responsible for Gulf-war syndrome. We studied the effect of a single (50 microg/kg/i.m) dose of sarin (0.5 x LD50) on the mRNA expression of alpha tubulin in the central nervous system (CNS) of rats which were sacrificed at different time points i.e. 1 and 2 hrs, as well as, 1, 3 and 7 days post-treatment. Northern data collected from CNS regions indicate differential, spatial, and temporal regulation of alpha tubulin mRNA levels. Immediate induction and persistence of alpha tubulin transcripts in sarin-treated CNS suggest that sarin-induced neurotoxicity is in part mediated by the altered expression of cytoskeletal genes which may be regulated at multiple levels.

Full Text

Duke Authors

Cited Authors

  • Damodaran, TV; Mecklai, AA; Abou-Donia, MB

Published Date

  • March 2002

Published In

Volume / Issue

  • 27 / 3

Start / End Page

  • 177 - 181

PubMed ID

  • 11958514

Pubmed Central ID

  • 11958514

International Standard Serial Number (ISSN)

  • 0364-3190

Language

  • eng

Conference Location

  • United States