Ethanol-inducible microsomal aniline hydroxylase activity and cytochrome P-450 isozymes in adult hen liver.


Journal Article

1. Cytochrome P-450 was induced in adult hen liver by administering 15% ethanol in drinking water and compared with other inducers such as phenobarbital and beta-naphthoflavone. 2. Aniline was the only substrate whose turnover was induced by ethanol treatment when measured in the presence of 100 microM alpha-naphthoflavone. 3. The inhibitor alpha-naphthoflavone differentiated aniline and p-nitrophenol hydroxylase activities, while p-hydroxyphenyl imidazole and SKF differentiated p-nitrophenol hydroxylase activity between ethanol- and beta-naphthoflavone-induced microsomes. 4. Ethanol treatment also slightly induced some P-450 isozymes related to phenobarbital and beta-naphthoflavone inducers.

Full Text

Duke Authors

Cited Authors

  • Gupta, RP; Abou-Donia, MB

Published Date

  • April 1, 1992

Published In

Volume / Issue

  • 101 / 3

Start / End Page

  • 505 - 512

PubMed ID

  • 1354126

Pubmed Central ID

  • 1354126

International Standard Serial Number (ISSN)

  • 0742-8413

Digital Object Identifier (DOI)

  • 10.1016/0742-8413(92)90078-l


  • eng

Conference Location

  • England