Anomalous phosphorylated neurofilament aggregations in central and peripheral axons of hens treated with tri-ortho-cresyl phosphate (TOCP).


Journal Article

Previous biochemical studies demonstrated a dramatic increase in phosphorylation of cytoskeletal proteins that occurs early in organophosphorus ester-induced delayed neurotoxicity (OPIDN). In this report we present immunohistochemical evidence that there is anomalous aggregation of phosphorylated neurofilaments within central and peripheral axons following organophosphate exposure. The morphology, location, and time of appearance of these aggregations are consistent with the hypothesis that the aberrant phosphorylation of cytoskeletal elements is an antecedent to the focal axonal swelling and degeneration characteristic of OPIDN.

Full Text

Duke Authors

Cited Authors

  • Jensen, KF; Lapadula, DM; Anderson, JK; Haykal-Coates, N; Abou-Donia, MB

Published Date

  • November 1992

Published In

Volume / Issue

  • 33 / 3

Start / End Page

  • 455 - 460

PubMed ID

  • 1469747

Pubmed Central ID

  • 1469747

Electronic International Standard Serial Number (EISSN)

  • 1097-4547

International Standard Serial Number (ISSN)

  • 0360-4012

Digital Object Identifier (DOI)

  • 10.1002/jnr.490330311


  • eng