Absence of delayed neurotoxicity and increased plasma butyrylcholinesterase activity in triallate-treated hens.

Published

Journal Article

Triallate (S-2,3,3-trichloroallyl diisopropylthiocarbamate) was tested for the potential to produce delayed neurotoxicity. Hens were given single oral doses ranging from 312.5 to 2500 mg/kg of triallate, 750 mg/kg tri-o-cresyl phosphate (TOCP), or empty gelatin capsules on Days 1 and 21 and were killed on Day 42. In a second experiment, animals were administered daily oral doses of 25-300 mg/kg triallate or 10 mg/kg TOCP for 90 days. In a third experiment, animals were given single oral doses of 2500 mg/kg triallate, 750 mg/kg TOCP, or empty gelatin capsules and killed after 24 hr. Delayed neurotoxicity was observed only in TOCP-treated animals. Animals given daily doses of 300 mg/kg triallate became moribund after 30 days; however, histological examination revealed no lesions characteristic of organophosphorus-induced delayed neurotoxicity. Neurotoxic esterase was not significantly altered in triallate-treated animals while it was 95% inhibited in TOCP-treated animals. Plasma butyrylcholinesterase increased significantly 24 hr after treatment with triallate in a dose-dependent manner. In summary, triallate, a thiocarbamate, did not produce neurotoxicity which has been previously reported for some dithiocarbamates.

Full Text

Duke Authors

Cited Authors

  • Lapadula, DM; Johannsen, F; Abou-Donia, MB

Published Date

  • January 1990

Published In

Volume / Issue

  • 14 / 1

Start / End Page

  • 191 - 198

PubMed ID

  • 2155148

Pubmed Central ID

  • 2155148

International Standard Serial Number (ISSN)

  • 0272-0590

Digital Object Identifier (DOI)

  • 10.1016/0272-0590(90)90244-e

Language

  • eng

Conference Location

  • United States