Absence of delayed neurotoxicity and increased plasma butyrylcholinesterase activity in triallate-treated hens.
Journal Article
Triallate (S-2,3,3-trichloroallyl diisopropylthiocarbamate) was tested for the potential to produce delayed neurotoxicity. Hens were given single oral doses ranging from 312.5 to 2500 mg/kg of triallate, 750 mg/kg tri-o-cresyl phosphate (TOCP), or empty gelatin capsules on Days 1 and 21 and were killed on Day 42. In a second experiment, animals were administered daily oral doses of 25-300 mg/kg triallate or 10 mg/kg TOCP for 90 days. In a third experiment, animals were given single oral doses of 2500 mg/kg triallate, 750 mg/kg TOCP, or empty gelatin capsules and killed after 24 hr. Delayed neurotoxicity was observed only in TOCP-treated animals. Animals given daily doses of 300 mg/kg triallate became moribund after 30 days; however, histological examination revealed no lesions characteristic of organophosphorus-induced delayed neurotoxicity. Neurotoxic esterase was not significantly altered in triallate-treated animals while it was 95% inhibited in TOCP-treated animals. Plasma butyrylcholinesterase increased significantly 24 hr after treatment with triallate in a dose-dependent manner. In summary, triallate, a thiocarbamate, did not produce neurotoxicity which has been previously reported for some dithiocarbamates.
Full Text
Cited Authors
- Lapadula, DM; Johannsen, F; Abou-Donia, MB
Published Date
- January 1990
Published In
Volume / Issue
- 14 / 1
Start / End Page
- 191 - 198
PubMed ID
- 2155148
Pubmed Central ID
- 2155148
International Standard Serial Number (ISSN)
- 0272-0590
Digital Object Identifier (DOI)
- 10.1016/0272-0590(90)90244-e
Language
- eng
Conference Location
- United States