Acceleration of anterograde axonal transport in cat sciatic nerve by diisopropyl phosphorofluoridate.


Journal Article

The effect of a neurotoxic dose of 5.0 mg/kg, s.c. diisopropyl phosphorofluoridate (DFP) on anterograde transport of 35S-methionine labeled proteins in cat peripheral nerve was studied. Seven days after dosing, after 24 h of flow there was 48% less radioactivity in the distal portion of the nerve. A lesser effect was also found at 4 and 14 days after dosing. After 10 or 14 h of flow, the height of the crest was unchanged, but the distance of the crest from the ganglia was greater in the DFP-treated animals. These experiments indicate that DFP treatment accelerates fast anterograde transport.

Full Text

Duke Authors

Cited Authors

  • Carrington, CD; Lapadula, DM; Abou-Donia, MB

Published Date

  • January 2, 1989

Published In

Volume / Issue

  • 476 / 1

Start / End Page

  • 179 - 182

PubMed ID

  • 2464416

Pubmed Central ID

  • 2464416

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(89)91555-2


  • eng

Conference Location

  • Netherlands