The time course of protection from delayed neurotoxicity induced by tri-o-cresyl phosphate and O,O-diisopropyl phosphorofluoridate by phenyl methyl sulfonyl fluoride in chickens.


Journal Article

The time dependence of the ability of phenyl methyl sulfonyl fluoride (PMSF) to protect adult hens from developing signs of paralysis following the administration of 750 mg/kg tri-ortho-cresyl phosphate (TOCP), p.o., of 1.7 mg/kg O,O-diisopropyl phosphorofluoridate (DFP), s.c., was investigated. PMSF was able to protect the hens from organophosphorus-induced delayed neurotoxicity (OPIDN) when given between 1 and 24 h before the administration of TOCP, or when given 4 h before DFP. However, PMSF was ineffective at preventing paralysis when given 24 h following dosing with TOCP or when given later than 4 h before DFP administration. These results support the notion that PMSF acts at the same site as the organophosphorus esters.

Full Text

Duke Authors

Cited Authors

  • Carrington, CD; Abou-Donia, MB

Published Date

  • September 1, 1983

Published In

Volume / Issue

  • 18 / 3

Start / End Page

  • 251 - 256

PubMed ID

  • 6665797

Pubmed Central ID

  • 6665797

International Standard Serial Number (ISSN)

  • 0378-4274

Digital Object Identifier (DOI)

  • 10.1016/0378-4274(83)90102-9


  • eng

Conference Location

  • Netherlands