Disposition, elimination and metabolism of O-ethyl O-4-nitrophenyl phenylphosphonothioate after subchronic dermal application in male cats.

Published

Journal Article

The metabolism, distribution, and excretion of the insecticide O-ethyl O-4-nitrophenyl phenylphosphonothioate (EPN) were studied in the male cat. Each cat was given a daily dermal dose of 0.5 mg/kg [14C]EPN for 10 consecutive days. Fifteen days after the last dose, the cats had excreted 62% of the cumulative dose in the urine and 10% in the feces. No 14CO2 was detected in the expired air. O-Ethyl phenylphosphonic acid (EPPA) was identified as the major urinary and fecal metabolite. Phenylphosphonic acid (PPA) was the second highest metabolite. Only traces of the intact EPN were recovered in the urine and feces. The disposition studies performed 1, 5, 10 and 15 days after the administration of the last dose showed that EPN was the major compound identified in the brain, spinal cord, sciatic nerve, adipose tissue, plasma and kidney. Most of the radioactivity in the liver was identified as EPPA followed by PPA. The time course of plasma EPN, determined after the 10th daily dose was biphasic. The slower process had a half-life of 17.0 days. After tissue distribution was completed, tissue elimination was adequately represented as a single first-order process.

Full Text

Duke Authors

Cited Authors

  • Abou-Donia, MB; Sivarajah, K; Abou-Donia, SA

Published Date

  • February 1, 1983

Published In

Volume / Issue

  • 26 / 2

Start / End Page

  • 93 - 111

PubMed ID

  • 6857694

Pubmed Central ID

  • 6857694

International Standard Serial Number (ISSN)

  • 0300-483X

Digital Object Identifier (DOI)

  • 10.1016/0300-483x(83)90061-6

Language

  • eng

Conference Location

  • Ireland