Ozone exposure modifies prostaglandin biosynthesis in perfused rat lungs.


Journal Article

Exposure of perfused rat lungs to 3.0 ppm of ozone produced a rapid onset of edema and an increased resistance to inflation. Both the Km and Vmax of the enzymic conversion of arachidonic acid to prostaglandins were decreased by ozone exposure suggesting an uncompetitive inhibition of prostaglandin synthetase by O3. Reduced glutathione failed to prevent the inhibition of prostaglandin synthesis by O3.

Full Text

Duke Authors

Cited Authors

  • Menzel, DB; Anderson, WG; Abou-Donia, MB

Published Date

  • September 1, 1976

Published In

Volume / Issue

  • 15 / 1

Start / End Page

  • 135 - 147

PubMed ID

  • 823617

Pubmed Central ID

  • 823617

International Standard Serial Number (ISSN)

  • 0034-5164


  • eng

Conference Location

  • United States