Ozone exposure modifies prostaglandin biosynthesis in perfused rat lungs.
Published
Journal Article
Exposure of perfused rat lungs to 3.0 ppm of ozone produced a rapid onset of edema and an increased resistance to inflation. Both the Km and Vmax of the enzymic conversion of arachidonic acid to prostaglandins were decreased by ozone exposure suggesting an uncompetitive inhibition of prostaglandin synthetase by O3. Reduced glutathione failed to prevent the inhibition of prostaglandin synthesis by O3.
Full Text
Duke Authors
Cited Authors
- Menzel, DB; Anderson, WG; Abou-Donia, MB
Published Date
- September 1, 1976
Published In
Volume / Issue
- 15 / 1
Start / End Page
- 135 - 147
PubMed ID
- 823617
Pubmed Central ID
- 823617
International Standard Serial Number (ISSN)
- 0034-5164
Language
- eng
Conference Location
- United States