Spin labeled acetylcholine analogs: studies of cholinergic receptor.

Published

Journal Article

Some spin-labeled acetylcholine analogs, in which the number of methylene groups between the quaternary nitrogen and the ether oxygen ranged between 1-5, were synthesized to study drug interacitons with acetylcholine receptors. None of the compounds tested, with the exception of the one that contained 2 methylene groups (SL-2) had any cholinergic activity. SL-2 was not capable of producing any nicotinic cholinomimetic activity. On the other hand it proved to have a very weak nicotinic cholinolytic activity on the receptors of the frog satorius muscle. This compound exhibited strong antagonism against muscarinic receptors of the isolated frog heart. The muscarinic cholinolytic action of the spin-label ACh analog is discussed in terms of the molecular perturbation theory of drug action.

Full Text

Duke Authors

Cited Authors

  • Rosen, GM; Abou-Donia, MB; Yeh, JZ; Menzel, DB

Published Date

  • October 1, 1975

Published In

Volume / Issue

  • 12 / 2

Start / End Page

  • 317 - 329

PubMed ID

  • 172996

Pubmed Central ID

  • 172996

International Standard Serial Number (ISSN)

  • 0034-5164

Language

  • eng

Conference Location

  • United States