Plasticity in mast cell responses during bacterial infections.

Journal Article (Review)

Mast cells (MCs) have been implicated in orchestrating the host's early innate immune and adaptive immune responses in several models of acute bacterial infections. Most of this activity results in early clearance of the bacteria and timely resolution of infection. However, during chronic infections because of the prolonged nature of MC-bacterial interactions, the role of the MC in determining the fate of infection is markedly more complex. Depending on the nature of the pathogen, severity of infection, and its association with a preexisting inflammatory disease, MCs may promote rather than contain chronic infections and exacerbate their pathological sequellae.

Full Text

Duke Authors

Cited Authors

  • Chan, CY; St John, AL; Abraham, SN

Published Date

  • February 2012

Published In

Volume / Issue

  • 15 / 1

Start / End Page

  • 78 - 84

PubMed ID

  • 22055570

Electronic International Standard Serial Number (EISSN)

  • 1879-0364

Digital Object Identifier (DOI)

  • 10.1016/j.mib.2011.10.007

Language

  • eng

Conference Location

  • England