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An allogenic cell-based implant for meniscal lesions.

Publication ,  Journal Article
Weinand, C; Peretti, GM; Adams, SB; Bonassar, LJ; Randolph, MA; Gill, TJ
Published in: Am J Sports Med
November 2006

BACKGROUND: Meniscal tears in the avascular zones do not heal. Although tissue-engineering approaches using cells seeded onto scaffolds could expand the indication for meniscal repair, harvesting autologous cells could cause additional trauma to the patient. Allogenic cells, however, could provide an unlimited amount of cells. HYPOTHESIS: Allogenic cells from 2 anatomical sources can repair lesions in the avascular region of the meniscus. STUDY DESIGN: Controlled laboratory study. METHODS: Both autologous and allogenic chondrocytes were seeded onto a Vicryl mesh scaffold and sutured into a bucket-handle lesion created in the medial menisci of 17 swine. Controls consisted of 3 swine knees treated with unseeded implants and controls from a previous experiment in which 4 swine were treated with suture only and 4 with no treatment. Menisci were harvested after 12 weeks and evaluated histologically for new tissue and percentage of interface healing surface; they were also evaluated statistically. RESULTS: The lesions were closed in 15 of 17 menisci. None of the control samples demonstrated healing. Histologic analysis of sequential cuts through the lesion showed formation of new scar-like tissue in all experimental samples. One of 8 menisci was completely healed in the allogenic group and 2 of 9 in the autologous group; the remaining samples were partially healed in both groups. No statistically significant differences in the percentage of healing were observed between the autologous and allogenic cell-based implants. CONCLUSION: Use of autologous and allogenic chondrocytes delivered via a biodegradable mesh enhanced healing of avascular meniscal lesions. CLINICAL RELEVANCE: This study demonstrates the potential of a tissue-engineered cellular repair of the meniscus using autologous and allogenic chondrocytes.

Duke Scholars

Published In

Am J Sports Med

DOI

ISSN

0363-5465

Publication Date

November 2006

Volume

34

Issue

11

Start / End Page

1779 / 1789

Location

United States

Related Subject Headings

  • Wound Healing
  • Transplantation, Homologous
  • Transplantation, Autologous
  • Tissue Engineering
  • Tibial Meniscus Injuries
  • Swine
  • Surgical Mesh
  • Orthopedics
  • Models, Animal
  • Chondrocytes
 

Citation

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ICMJE
MLA
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Weinand, C., Peretti, G. M., Adams, S. B., Bonassar, L. J., Randolph, M. A., & Gill, T. J. (2006). An allogenic cell-based implant for meniscal lesions. Am J Sports Med, 34(11), 1779–1789. https://doi.org/10.1177/0363546506290666
Weinand, Christian, Giuseppe M. Peretti, Samuel B. Adams, Lawrence J. Bonassar, Mark A. Randolph, and Thomas J. Gill. “An allogenic cell-based implant for meniscal lesions.Am J Sports Med 34, no. 11 (November 2006): 1779–89. https://doi.org/10.1177/0363546506290666.
Weinand C, Peretti GM, Adams SB, Bonassar LJ, Randolph MA, Gill TJ. An allogenic cell-based implant for meniscal lesions. Am J Sports Med. 2006 Nov;34(11):1779–89.
Weinand, Christian, et al. “An allogenic cell-based implant for meniscal lesions.Am J Sports Med, vol. 34, no. 11, Nov. 2006, pp. 1779–89. Pubmed, doi:10.1177/0363546506290666.
Weinand C, Peretti GM, Adams SB, Bonassar LJ, Randolph MA, Gill TJ. An allogenic cell-based implant for meniscal lesions. Am J Sports Med. 2006 Nov;34(11):1779–1789.
Journal cover image

Published In

Am J Sports Med

DOI

ISSN

0363-5465

Publication Date

November 2006

Volume

34

Issue

11

Start / End Page

1779 / 1789

Location

United States

Related Subject Headings

  • Wound Healing
  • Transplantation, Homologous
  • Transplantation, Autologous
  • Tissue Engineering
  • Tibial Meniscus Injuries
  • Swine
  • Surgical Mesh
  • Orthopedics
  • Models, Animal
  • Chondrocytes