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CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation.

Publication ,  Journal Article
Peranteau, WH; Endo, M; Adibe, OO; Merchant, A; Zoltick, PW; Flake, AW
Published in: Blood
December 15, 2006

In utero hematopoietic-cell transplantation (IUHCT) can induce donor-specific tolerance to facilitate postnatal transplantation. Induction of tolerance requires a threshold level of mixed hematopoietic chimerism. CD26 is a peptidase whose inhibition increases homing and engraftment of hematopoietic cells in postnatal transplantation. We hypothesized that CD26 inhibition would increase donor-cell homing to the fetal liver (FL) and improve allogeneic engraftment following IUHCT. To evaluate this hypothesis, B6GFP bone marrow (BM) or enriched hematopoietic stem cells (HSCs) were transplanted into allogeneic fetal mice with or without CD26 inhibition. Recipients were analyzed for FL homing and peripheral-blood chimerism from 4 to 28 weeks of life. We found that CD26 inhibition of donor cells results in (1) increased homing of allogeneic BM and HSCs to the FL, (2) an increased number of injected animals with evidence of postnatal engraftment, (3) increased donor chimerism levels following IUHCT, and (4) a competitive engraftment advantage over noninhibited congenic donor cells. This study supports CD26 inhibition as a potential method to increase the level of FL homing and engraftment following IUHCT. The resulting increased donor chimerism suggests that CD26 inhibition may in the future be used as a method of increasing donor-specific tolerance following IUHCT.

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Published In

Blood

DOI

ISSN

0006-4971

Publication Date

December 15, 2006

Volume

108

Issue

13

Start / End Page

4268 / 4274

Location

United States

Related Subject Headings

  • Uterus
  • Transplantation, Homologous
  • Transplantation Chimera
  • Pregnancy
  • Oligopeptides
  • Mice, Inbred BALB C
  • Mice
  • Liver
  • Immunosuppression Therapy
  • Immunology
 

Citation

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Chicago
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Peranteau, W. H., Endo, M., Adibe, O. O., Merchant, A., Zoltick, P. W., & Flake, A. W. (2006). CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. Blood, 108(13), 4268–4274. https://doi.org/10.1182/blood-2006-04-018986
Peranteau, William H., Masayuki Endo, Obinna O. Adibe, Aziz Merchant, Philip W. Zoltick, and Alan W. Flake. “CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation.Blood 108, no. 13 (December 15, 2006): 4268–74. https://doi.org/10.1182/blood-2006-04-018986.
Peranteau WH, Endo M, Adibe OO, Merchant A, Zoltick PW, Flake AW. CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. Blood. 2006 Dec 15;108(13):4268–74.
Peranteau, William H., et al. “CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation.Blood, vol. 108, no. 13, Dec. 2006, pp. 4268–74. Pubmed, doi:10.1182/blood-2006-04-018986.
Peranteau WH, Endo M, Adibe OO, Merchant A, Zoltick PW, Flake AW. CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. Blood. 2006 Dec 15;108(13):4268–4274.

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

December 15, 2006

Volume

108

Issue

13

Start / End Page

4268 / 4274

Location

United States

Related Subject Headings

  • Uterus
  • Transplantation, Homologous
  • Transplantation Chimera
  • Pregnancy
  • Oligopeptides
  • Mice, Inbred BALB C
  • Mice
  • Liver
  • Immunosuppression Therapy
  • Immunology