Simulation of aggregation in Dictyostelium using the Cell Programming Language.

Journal Article (Journal Article)

In developmental biology, modeling and simulation play an important role in understanding cellular interactions. We suggest a simple language, the Cell Programming Language (CPL), to write computer programs to describe this behavior. Using these programs, it is possible to simulate and visualize intercellular behavior. We employ CPL to model aggregation in Dictyostelium in response to a chemotactic agent. CPL programs are utilized to model a variety of aggregation behavior including streaming, spiral formation and the effect of amoeba density on aggregation patterns. We believe CPL is a useful tool for developing, understanding and checking biological models that utilize cellular interactions.

Full Text

Duke Authors

Cited Authors

  • Agarwal, P

Published Date

  • December 1994

Published In

Volume / Issue

  • 10 / 6

Start / End Page

  • 647 - 655

PubMed ID

  • 7704663

International Standard Serial Number (ISSN)

  • 0266-7061

Digital Object Identifier (DOI)

  • 10.1093/bioinformatics/10.6.647


  • eng