Beta-arrestin-mediated signaling regulates protein synthesis.
Journal Article (Journal Article)
Seven transmembrane receptors (7TMRs) exert strong regulatory influences on virtually all physiological processes. Although it is historically assumed that heterotrimeric G proteins mediate these actions, there is a newer appreciation that beta-arrestins, originally thought only to desensitize G protein signaling, also serve as independent receptor signal transducers. Recently, we found that activation of ERK1/2 by the angiotensin receptor occurs via both of these distinct pathways. In this work, we explore the physiological consequences of beta-arrestin ERK1/2 signaling and delineate a pathway that regulates mRNA translation and protein synthesis via Mnk1, a protein that both physically interacts with and is activated by beta-arrestins. We show that beta-arrestin-dependent activation of ERK1/2, Mnk1, and eIF4E are responsible for increasing translation rates in both human embryonic kidney 293 and rat vascular smooth muscle cells. This novel demonstration that beta-arrestins regulate protein synthesis reveals that the spectrum of beta-arrestin-mediated signaling events is broader than previously imagined.
Full Text
Duke Authors
Cited Authors
- DeWire, SM; Kim, J; Whalen, EJ; Ahn, S; Chen, M; Lefkowitz, RJ
Published Date
- April 18, 2008
Published In
Volume / Issue
- 283 / 16
Start / End Page
- 10611 - 10620
PubMed ID
- 18276584
Pubmed Central ID
- PMC2447657
International Standard Serial Number (ISSN)
- 0021-9258
Digital Object Identifier (DOI)
- 10.1074/jbc.M710515200
Language
- eng
Conference Location
- United States