Relation between time from myocardial infarction to enrolment and patient outcomes in the Multicenter UnSustained Tachycardia Trial.

Published

Journal Article

AIMS: We sought to assess the relation between time from myocardial infarction (MI) to enrolment and patient outcomes and to examine the association between these outcomes and implantable cardioverter defibrillator (ICD) therapy. METHODS AND RESULTS: We analysed the Multicenter UnSustained Tachycardia Trial database (n = 1650). In examining all endpoints, Cox proportional hazards models were used to adjust for potential confounders. There was no significant association between time from MI to enrolment and any of the outcomes (P > 0.1). Inducibility by an electrophysiology study (EPS) was associated with a higher risk of arrhythmic death or cardiac arrest [adjusted hazard ratio (HR) 2.51; 95% confidence interval (CI) 1.64-3.84] and all-cause death (adjusted HR 1.45; 95% CI 1.04-2.03) only in patients who had an MI 6 months before enrolment (adjusted HR 0.34; 95% CI 0.21-0.54). CONCLUSION: The risk of arrhythmic death or cardiac arrest and all-cause death did not vary as a function of time from the most recent MI to enrolment. Inducibility by an EPS was associated with worse outcomes only in patients with an MI

Full Text

Duke Authors

Cited Authors

  • Al-Khatib, SM; Hafley, G; Lee, KL; Buxton, AE

Published Date

  • August 2010

Published In

Volume / Issue

  • 12 / 8

Start / End Page

  • 1112 - 1118

PubMed ID

  • 20452992

Pubmed Central ID

  • 20452992

Electronic International Standard Serial Number (EISSN)

  • 1532-2092

Digital Object Identifier (DOI)

  • 10.1093/europace/euq116

Language

  • eng

Conference Location

  • England