Development of DX-9065a, a novel direct factor Xa antagonist, in cardiovascular disease.

Journal Article (Journal Article;Review)

The development of anticoagulants for treating patients with atherothrombotic disorders of the arterial circulatory system has focused, either directly or indirectly, on thrombin - a pleuripotential effector enzyme with prothrombotic and proinflammatory properties. The pivotal role of factor (f) Xa in thrombin generation, coupled with its direct cellular effects and widely recognized limitations of currently available anticoagulants, has led to the development of pharmacologic inhibitors of this important protease. The following review focuses on DX-9065a - first in a class of direct, selective and reversible fXa antagonists - and its potential applications in the management of patients with cardiovascular disease.

Full Text

Duke Authors

Cited Authors

  • Becker, RC; Alexander, J; Dyke, CK; Harrington, RA

Published Date

  • December 2004

Published In

Volume / Issue

  • 92 / 6

Start / End Page

  • 1182 - 1193

PubMed ID

  • 15583722

International Standard Serial Number (ISSN)

  • 0340-6245

Digital Object Identifier (DOI)

  • 10.1160/TH04-05-0289


  • eng

Conference Location

  • Germany