Bleeding after antithrombotic therapy in patients with acute ischemic heart disease

Journal Article

Definitions of bleeding must be considered when evaluating results of clinical trials. Assessments of bleeding impact based on clinical criteria may be more relevant to patient outcomes than those based on simple laboratory measures like an isolated change in hemoglobin, that do not appear to affect patient care. The risk of excessive bleeding in patients who receive antiplatelet and antithrombotic therapy is related to a combination of patient characteristics (older age, female sex, impaired renal function), and delivery factors (excessive dosing, stacking of anticoagulants). Investigators should justify components of bleeding endpoints as being clinically meaningful, sufficiently frequent in the study population, and affected by the intervention. © Springer Science+Business Media, LLC 2007.

Full Text

Duke Authors

Cited Authors

  • Cohen, M; Alexander, KP; Rao, SV

Published Date

  • 2008

Published In

Volume / Issue

  • 26 / 3

Start / End Page

  • 175 - 182

PubMed ID

  • 18080799

International Standard Serial Number (ISSN)

  • 0929-5305

Digital Object Identifier (DOI)

  • 10.1007/s11239-007-0182-x