Overcoming drug resistance in mantle cell lymphoma using a combination of dose-dense and intense therapy.
Journal Article
We present a study of the prevalence of genetic polymorphisms and expression of genes encoding the drug-resistance proteins glutathione S-transferases (GSTs) in order to gain insights into the pattern of failure evident in mantle cell lymphoma. We note a high preponderance of genetic alterations conferring resistance to standard chemotherapy in this illness. Concurrent with this investigation, we present a series of patients who were provided dose-dense and intense chemotherapy to circumvent these drug-resistance mechanisms. High responses were noted, though durable remissions were few, indicating non-traditional chemotherapy options are important to investigate in this illness.
Full Text
Duke Authors
- Ali-Osman, Francis
- Chao, Nelson Jen An
- de Castro III, Carlos Manuel
- Diehl, Louis Frederic
- Gasparetto, Cristina
- Gockerman, Jon Paul
- Horwitz, Mitchell Eric
- Long, Gwynn Douglas
- Moore, Joseph Odell
- Niedzwiecki, Donna
- Rizzieri, David Alan
Cited Authors
- Crout, CA; Koh, L-P; Gockerman, JP; Moore, JO; Decastro, C; Long, GD; Diehl, L; Gasparetto, C; Niedzwiecki, D; Edwards, J; Prosnitz, L; Horwitz, M; Chute, J; Morris, A; Davis, P; Beaven, A; Chao, NJ; Ali-Osman, F; Rizzieri, DA
Published Date
- July 2010
Published In
Volume / Issue
- 28 / 6
Start / End Page
- 654 - 660
PubMed ID
- 20521909
Electronic International Standard Serial Number (EISSN)
- 1532-4192
Digital Object Identifier (DOI)
- 10.3109/07357901003631015
Language
- eng
Conference Location
- England