Control for confounding in case-control studies using the stratification score, a retrospective balancing score.
The stratification score for a case-control study is the probability of disease modeled as a function of potential confounders. The authors show that the stratification score is a retrospective balancing score and thus plays a similar role in case-control studies as the propensity score plays in prospective studies. The authors further show how standardization using the stratification score can be used to compare the distributions of exposures that would be found among case and control participants if both groups had the same distribution of confounding covariables. The authors illustrate these results using data from a genome-wide association study, the GAIN (Genetic Association Information Network) study of schizophrenia among African Americans (2006-2008).
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Related Subject Headings
- Schizophrenia
- Retrospective Studies
- Propensity Score
- Probability
- Models, Statistical
- Humans
- Genome-Wide Association Study
- Epidemiology
- Epidemiologic Research Design
- Confounding Factors, Epidemiologic
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Schizophrenia
- Retrospective Studies
- Propensity Score
- Probability
- Models, Statistical
- Humans
- Genome-Wide Association Study
- Epidemiology
- Epidemiologic Research Design
- Confounding Factors, Epidemiologic