Potential mechanisms for reduced delivery of nitric oxide to peripheral tissues in diabetes mellitus.

Journal Article (Journal Article;Review)

Nitric oxide (NO) bioavailability is crucial for normal vascular endothelial function and health. Recent studies have demonstrated an endocrine role for NO equivalents that may be transported in the blood to peripheral tissue beds, where under hypoxic conditions they can liberate NO and cause vasodilation. Exercise training improves endothelial function but its effect on NO bioavailability in peripheral tissues during acute exercise stress in CVD is unclear. This paper will present evidence and discuss possible mechanisms by which NO delivery to peripheral tissues may be dysfunctional in diabetic subjects.

Full Text

Duke Authors

Cited Authors

  • Stabler, T; Kenjale, A; Ham, K; Jelesoff, N; Allen, J

Published Date

  • August 2010

Published In

Volume / Issue

  • 1203 /

Start / End Page

  • 101 - 106

PubMed ID

  • 20716290

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

Digital Object Identifier (DOI)

  • 10.1111/j.1749-6632.2010.05599.x


  • eng

Conference Location

  • United States