Lower-limb vascular imaging with acoustic radiation force elastography: demonstration of in vivo feasibility.

Journal Article (Journal Article)

Acoustic radiation force impulse (ARFI) imaging characterizes the mechanical properties of tissue by measuring displacement resulting from applied ultrasonic radiation force. In this paper, we describe the current status of ARFI imaging for lower-limb vascular applications and present results from both tissue-mimicking phantoms and in vivo experiments. Initial experiments were performed on vascular phantoms constructed with polyvinyl alcohol for basic evaluation of the modality. Multilayer vessels and vessels with compliant occlusions of varying plaque load were evaluated with ARFI imaging techniques. Phantom layers and plaque are well resolved in the ARFI images, with higher contrast than B-mode, demonstrating the ability of ARFI imaging to identify regions of different mechanical properties. Healthy human subjects and those with diagnosed lower-limb peripheral arterial disease were imaged. Proximal and distal vascular walls are well visualized in ARFI images, with higher mean contrast than corresponding B-mode images. ARFI images reveal information not observed by conventional ultrasound and lend confidence to the feasibility of using ARFI imaging during lower-limb vascular workup.

Full Text

Duke Authors

Cited Authors

  • Dumont, D; Dahl, J; Miller, E; Allen, J; Fahey, B; Trahey, G

Published Date

  • May 2009

Published In

Volume / Issue

  • 56 / 5

Start / End Page

  • 931 - 944

PubMed ID

  • 19473912

Pubmed Central ID

  • PMC2813206

Electronic International Standard Serial Number (EISSN)

  • 1525-8955

International Standard Serial Number (ISSN)

  • 0885-3010

Digital Object Identifier (DOI)

  • 10.1109/tuffc.2009.1126


  • eng