Lack of association between LOXL1 gene polymorphisms and primary open angle glaucoma in the Saudi Arabian population.

Published

Journal Article

To investigate whether major single nucleotide polymorphisms (SNPs) in the LOXL1 gene associated with pseudoexfoliation glaucoma are associated with primary open angle glaucoma (POAG) in the Saudi Arabian population.The regions of the LOXL1 gene associated with pseudoexfoliation glaucoma, encompassing the three common SNPs, (rs1048661, rs3825942 and rs2165241), were sequenced in a Saudi Arabian dataset consisting of 96 POAG cases and 101 healthy controls.The allele frequency of the G exfoliation risk allele for SNP rs1048661 in POAG cases and controls was 0.75 and 0.76 (p = 0.886), respectively and the allele frequency difference was not statistically significant (p = 0.866). There was no statistically significant difference in the genotypes between patients and controls (p = 0.261 and 0.156 for genotypes G/G and G/T respectively). As for SNP rs3825942, the frequency of the "G" allele in the POAG patients was comparable to that in the controls (p = 0.477) and there was no statistically significant difference in genotype G/G and A/G frequency in the study groups. As for SNP rs2165241, the "T" allele frequency in the POAG patients (0.46) was slightly higher than the frequency in controls (0.39), but this difference was not statistically significant (p = 0.176).The Saudi Arabian POAG population, similar to all other populations studied to date, demonstrates no association with SNPs associated with pseudoexfoliation glaucoma.

Full Text

Duke Authors

Cited Authors

  • Abu-Amero, KK; Osman, EA; Azad, MT; Allingham, RR; Hauser, MA; Al-Obeidan, SA

Published Date

  • September 2012

Published In

Volume / Issue

  • 33 / 3

Start / End Page

  • 130 - 133

PubMed ID

  • 21510775

Pubmed Central ID

  • 21510775

Electronic International Standard Serial Number (EISSN)

  • 1744-5094

International Standard Serial Number (ISSN)

  • 1381-6810

Digital Object Identifier (DOI)

  • 10.3109/13816810.2011.575430

Language

  • eng