Effects of electroconvulsive therapy in adolescents with severe endogenous depression resistant to pharmacotherapy.

Journal Article (Clinical Trial;Journal Article)

BACKGROUND: This open, prospective study examined the effects of electroconvulsive therapy (ECT) in 10 adolescents with primary, endogenous, psychotic depression who were resistant to antidepressant pharmacotherapy. METHODS: Change in symptom severity from baseline was assessed weekly with Hamilton Depression Rating Scale (HDRS) ratings, and outcome was measured additionally at 1 month, and again at 1 year, post-ECT. RESULTS: All but 1 patient demonstrated dramatic improvement, with statistically significant decreases in mean HDRS score detected after the first week of treatment. All responders maintained the benefits of their treatment. CONCLUSIONS: The results provide evidence of the clinical effectiveness of ECT in adolescents with phenomenological characteristics shown to be predictive of ECT response in adults.

Full Text

Duke Authors

Cited Authors

  • Strober, M; Rao, U; DeAntonio, M; Liston, E; State, M; Amaya-Jackson, L; Latz, S

Published Date

  • March 1, 1998

Published In

Volume / Issue

  • 43 / 5

Start / End Page

  • 335 - 338

PubMed ID

  • 9513748

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/s0006-3223(97)00205-9


  • eng

Conference Location

  • United States