Intraurethral activation of excitatory bladder reflexes in persons with spinal cord injury


Journal Article

Electrical activation of an excitatory reflex between sensory fibers in the pudendal nerve and the bladder has been demonstrated in cats and is a potential means of restoring micturition function in persons with spinal cord injury. We investigated the clinical feasibility of activating this reflex to restore bladder function in persons with spinal cord injury by using intraurethral electrical stimulation to activate pudendal sensory fibers innervating the urethra. Excitatory bladder responses (contractions) were evoked by trains of electrical pulses applied to either the proximal (29.7 ± 11.6 cmH 2O) or distal (30.2 ± 11.6 cmH2O) segment of the urethra. The results indicate that an excitatory reflex between pudendal nerve afferents and the bladder exists in humans with spinal injury and may provide a substrate for restoring micturition function. ©2009 IEEE.

Full Text

Duke Authors

Cited Authors

  • Yoo, PB; Horvath, EE; Amundsen, CL; Webster, GD; Grill, WM

Published Date

  • January 1, 2009

Published In

  • Proceedings of the 31st Annual International Conference of the Ieee Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, Embc 2009

Start / End Page

  • 6781 - 6784

Digital Object Identifier (DOI)

  • 10.1109/IEMBS.2009.5333982

Citation Source

  • Scopus